In enzymology, a diacylglycerol cholinephosphotransferase (EC 2.7.8.2) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylcholine.
Classification
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups.
Nomenclature
The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include:
Biological role
This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.
References
- Lee TC, Blank ML, Fitzgerald V, Snyder F (1982). "Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver". Biochim. Biophys. Acta. 713 (2): 479–83. doi:10.1016/0005-2760(82)90269-7. PMID 6295501.
- Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ (1978). "Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate". Lipids. 13 (2): 161–4. doi:10.1007/BF02533260. PMID 204847.
- Renooij W, Snyder F (1981). "Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues". Biochim. Biophys. Acta. 663 (2): 545–56. doi:10.1016/0005-2760(81)90182-x. PMID 6260215.
